Ailanthone Inhibits Cell Proliferation in Tongue Squamous Cell Carcinoma via PI3K/AKT Pathway

Figure 2

AIL induced apoptosis in TSCC by influencing Bcl-2/Bax ratio and caspase expression. (a) The levels of Bax and Bcl-2 in Cal-27 cells subjected to AIL treatment were assessed by western blotting. (b) Statistical study of the Bcl-2/Bax ratio in Cal-27 cells with or without AIL. versus the control. (c-d) Western blotting analysis of the levels of PARP1, caspase-3 and -9, cleaved PARP1, and cleaved caspase-3 and -9 in AIL-treated Cal-27 cells. , , and versus the control. (e-f) Western blotting analysis of the protein expression of Bcl-2 and Bax in TCA8113 cells treated with or without AIL. versus the control. (g-h) Western blotting analysis of the levels of PARP1, caspase-3 and -9, cleaved PARP1, and cleaved caspase-3 and -9 in AIL-treated TCA8113 cells. , , and versus the control.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)