Pharmacological Activity of Quercetin: An Updated Review

Table 2

Study of quercetin’s in vitro and in vitroanti-inflammatory activity.

Disease types	Quercetin/derivatives	Study models	Effects/molecular mechanisms	Ref.
Endotoxin-induced inflammatory response	Quercetin and quercitrin	RAW264.7 cells	Reduce TNF-α, IL-1β, and IL-6	[4]
—	Quercetin	H9C2 cells	Promote PVT1 expression	[24]
Rheumatoid arthritis	Quercetin	Eight-week-old male C57BL/6 mice	Inhibit neutrophil infiltration	[82]
Surgical-induced osteoarthritis	Quercetin	New Zealand White rabbits	Upregulate SOD and TIMP-1, downregulate MMP-13, inhibiting the degradation of cartilage extracellular matrix	[85]
LPS-induced oxidative stress and inflammation	Quercetin	A549 cells	Suppress the nuclear translocation of NF-κB, reduce levels of inflammatory cytokine tumor necrosis factor (TNF)-α, interleukin (IL)-1, and IL-6	[87]
LPS/interferon γ-induced nitric oxide production	Quercetin and heat shock protein HSC70	RAW264.7 cells	Inhibit enhancement of TNF-α and the production of RANTES	[88]
TNF-α induced inflammation	Quercetin	Human umbilical vein endothelial cells	Block NF-κB and AP-1 signaling pathway	[89]
CCl4-induced inflammation	Quercetin	Male mice (20–25 g)	Inhibit ROS production in the liver and attenuate CCl4-induced oxidative damage	[90]