Citrus unshiu Peel Attenuates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice due to Modulation of the PI3K/Akt Signaling Pathway and MAPK and NF-κB

Figure 2

Citrus unshiu peel improved changes in body weight, colon tissue length, and histological analysis in UC. (a) Change body weight; (b) change in colon length; (c) MPO (myeloperoxidase); (d) histological analysis; (e) histological score. Hematoxylin and eosin (H&E) staining. Blue arrows indicate inflammatory cells infiltration. Magnification ×100 and ×200 (scale bar = 100 μm). Histological analysis was measured using ImageJ program (NIH). Control: control mice, DSS: distilled water administered to ulcerative colitis mice, SASP: sulfasalazine 100 mg/kg body weight administered to ulcerative colitis mice, CUPL: CUP 100 mg/kg body weight administered to ulcerative colitis mice, and CUPH: CUP 200 mg/kg body weight administered to ulcerative colitis mice. Data are mean ± SD (n = 8). Significance: and vs. control mice, , , and vs. DSS mice.

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