Citrus unshiu Peel Attenuates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice due to Modulation of the PI3K/Akt Signaling Pathway and MAPK and NF-κB

Figure 7

Citrus unshiu peel inhibited NF-κBp65, inflammatory mediators, and proinflammatory cytokines. Control: control mice, DSS: distilled water administered to ulcerative colitis mice, SASP: sulfasalazine 100 mg/kg body weight administered to ulcerative colitis mice, CUPL: CUP 100 mg/kg body weight administered to ulcerative colitis mice, and CUPH: CUP 200 mg/kg body weight administered to ulcerative colitis mice. Data are mean ± SD (n = 8). Significance: and vs. control mice, , , and vs. DSS mice.