Bombyx batryticatus Cocoonase Inhibitor Separation, Purification, and Inhibitory Effect on the Proliferation of SMCC-7721 HeLa-Derived Cells

Table 5

Tumor inhibition rate of BBCI on SMCC-7721 cells in tumor-bearing mice and the spleen coefficient.

Group	Dose (mg.kg^−1)	Tumor weight (g)	Tumor inhibition rate (%)	Spleen coefficient (mg/g)
Control	0	0.38 ± 0.19	0	5.27
5-Fu	20.00	0.29 ± 0.16	23.68	5.18
BBCI	12.50	0.35 ± 0.14	9.68	5.36
	25.00	0.27 ± 0.11	31.43	5.63
	50.00	0.23 ± 0.09^,a	55.56	5.44

Conducted in triplicate. Tumor weight and spleen coefficient values are the mean ± SD. , compared with the control group. ^a, compared with the positive control group. BBCI: Bombyx batryticatus cocoonase inhibitor.