Efficacy of Rubus coreanus Miq. and Astragalus membranaceus Bunge Extract for Postmenopausal Syndrome: A Randomised, Double-Blind, Placebo Comparative Clinical Trial
Table 2
Outcomes and safety (PP set).
RCAM group
Placebo group
#value
Mean (SD)
Mean (SD)
Primary outcome
Kupperman index
Visit 2
29.00 (5.722)
30.24 (7.034)
.467
Visit 5
13.82 (6.645)
20.00 (9.666)
.007
Secondary outcome
MRS
Visit 2
20.39 (8.052)
23.79 (6.383)
.082
Visit 5
9.36 (4.893)
13.45 (5.736)
.005
Total cholesterol
Visit 2
215.43 (36.613)
199.83 (35.783)
.467
Visit 5
220.71 (34.115)
211.52 (42.524)
.007
TG
Visit 2
99.00 (46.555)
141.31 (82.295)
.021
Visit 5
129.04 (64.766)
155.76 (85.061)
.189
LDL-C
Visit 2
120.46 (22.401)
113.75 (25.182)
.293
Visit 5
126.00 (25.197)
122.41 (31.072)
.635
HDL-C
Visit 2
64.61 (16.176)
55.59 (12.191)
.022
Visit 5
63.25 (12.539)
56.97 (11.912)
.057
Safety
AST (GOT)
Visit 2
27.49 (16.217)
26.13 (6.808)
.637
Visit 5
22.58 (3.519)
25.07 (4.315)
.016
ALT (GPT)
Visit 2
21.59 (12.156)
23.15 (10.067)
.538
Visit 5
17.77 (5.025)
23.50 (9.591)
.006
γGTP
Visit 2
20.67 (14.930)
22.31 (17.535)
.658
Visit 5
17.71 (5.917)
21.80 (11.376)
.087
ALP
Visit 2
71.03 (18.876)
76.08 (20.958)
.267
Visit 5
68.84 (16.448)
77.57 (21.188)
.077
Total protein
Visit 2
0.73 (0.270)
0.66 (0.213)
.192
Visit 5
0.78 (0.338)
0.71 (0.221)
.347
Albumin
Visit 2
4.58 (0.195)
4.47 (0.198)
.015
Visit 5
4.55 (0.196)
4.55 (0.191)
.972
BUN
Visit 2
15.58 (4.096)
14.60 (3.145)
.240
Visit 5
16.08 (4.935)
16.08 (3.527)
.995
Creatinine
Visit 2
0.74 (0.080)
0.74 (0.098)
.678
Visit 5
0.73 (0.077)
0.75 (0.113)
.529
Uric acid
Visit 2
4.45 (0.882)
4.35 (0.820)
.634
Visit 5
4.35 (0.841)
4.22 (0.875)
.551
Glucose
Visit 2
96.08 (18.190)
94.36 (13.443)
.637
Visit 5
93.32 (14.358)
93.93 (12.029)
.858
CRP
Visit 2
0.12 (0.213)
0.11 (0.157)
.795
Visit 5
0.08 (0.080)
0.12 (0.266)
.440
ESR
Visit 2
9.77 (4.732)
10.28 (4.963)
.642
Visit 5
9.13 (2.323)
9.23 (3.441)
.889
Endometrial thickness
Visit 2
2.43 (1.049)
2.49 (0.867)
.761
Visit 5
2.47 (1.002)
2.35 (0.951)
.621
E2
Visit 2
13.76 (48.753)
12.10 (27.094)
.853
Visit 5
14.20 (29.215)
13.45 (28.678)
.920
FSH
Visit 2
79.00 (23.254)
77.53 (26.863)
.796
Visit 5
80.41 (23.182)
76.88 (21.781)
.543
LH
Visit 2
39.66 (13.913)
35.23 (15.965)
.195
Visit 5
40.18 (13.393)
38.54 (14.341)
.647
< .05 < .01 , and < .001 . #: independent two-sample t-test, the RCAM group vs. the placebo group. †: paired t-test, visit 2 vs. visit 5.
