Comprehensive Computational Analysis of Honokiol Targets for Cell Cycle Inhibition and Immunotherapy in Metastatic Breast Cancer Stem Cells

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left">Rank</td><td class="align_center">Gene symbol</td><td class="align_center">MCC score</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">1</td><td class="align_center">HSP90AA1</td><td class="align_center">132</td></tr><tr><td class="align_left">2</td><td class="align_center">PARP1</td><td class="align_center">102</td></tr><tr><td class="align_left">3</td><td class="align_center"><i>CCND1</i></td><td class="align_center">98</td></tr><tr><td class="align_left">4</td><td class="align_center">HDAC1</td><td class="align_center">67</td></tr><tr><td class="align_left">5</td><td class="align_center">HSP90AB1</td><td class="align_center">62</td></tr><tr><td class="align_left">6</td><td class="align_center">VEGFA</td><td class="align_center">53</td></tr><tr><td class="align_left">7</td><td class="align_center">CASP9</td><td class="align_center">28</td></tr><tr><td class="align_left">8</td><td class="align_center">AURKB</td><td class="align_center">26</td></tr><tr><td class="align_left">9</td><td class="align_center">HDAC6</td><td class="align_center">24</td></tr><tr><td class="align_left">10</td><td class="align_center">SIRT2</td><td class="align_center">18</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Top-10 hub genes by Maximal Clique Centrality (MCC) score, as analyzed by CytoHubba.</div>

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Table 2

Table 2: Comprehensive Computational Analysis of Honokiol Targets for Cell Cycle Inhibition and Immunotherapy in Metastatic Breast Cancer Stem Cells 