Network Pharmacology and In Vivo Analysis of Dahuang-Huangqi Decoction Effectiveness in Alleviating Renal Interstitial Fibrosis

<div>Dahuang-Huangqi decoction (DHHQD) treatment minimizes transforming growth factor (TGF)-<i>β</i>1 and <i>α</i>-smooth muscle actin (<i>α</i>-SMA) deposition in the kidneys of unilateral ureteral obstruction (UUO) rats. (a) The protein expression of TGF-<i>β</i>1 and <i>α</i>-SMA was determined by immunohistochemistry at 400× magnification. Positive staining is brown. (b) The positive area is expressed as the mean percentage ± SD for each experimental group. The protein expression of TGF-<i>β</i>1 and <i>α</i>-SMA was slightly lower in the DHHQD-H group than in the DHHQD-L group. 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Evidence-Based Complementary and Alternative Medicine

fig10

Figure 10

Figure 10: Network Pharmacology and In Vivo Analysis of Dahuang-Huangqi Decoction Effectiveness in Alleviating Renal Interstitial Fibrosis 