Network Pharmacology and In Vivo Analysis of Dahuang-Huangqi Decoction Effectiveness in Alleviating Renal Interstitial Fibrosis

Figure 9

Effect of Dahuang-Huangqi decoction (DHHQD) as assessed by transmission electron microscopy (TEM) of renal tissue samples (10,000×). (a) The UUO group presented glomerular basement membrane thickening (brown arrow) and mesangial matrix increase, accompanied by extensive podocyte fusion (yellow arrow). These pathological changes were alleviated in the DHHQD-H and DHHQD-L groups. The DHHQD-H group was slightly improved compared with the DHHQD-L group. (b) Collagenous fibers (red arrow) in renal interstitial tissues increased significantly in the UUO group and decreased in the DHHQD-H and DHHQD-L groups. The collagenous fibers were slightly fewer in the DHHQD-H group than in the DHHQD-L group. DHHQD-H, Dahuang-Huangqi decoction high dose; DHHQD-L, Dahuang-Huangqi decoction low dose.

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