Plant Bioactives in the Treatment of Inflammation of Skeletal Muscles: A Molecular Perspective

Table 2

Clinical trials testing the efficacy of the medicinal herbs and plant bioactives in the treatment of musculoskeletal inflammation.

Sr. no.	Title	Status	Conditions	Interventions	Characteristics	NCT number
1.	Aloe vera ointment application and skeletal muscle recovery	Completed	(i) Skeletal muscle damage; (ii) Exercise-induced aseptic inflammation; (iii) Performance	(i) Biological: placebo; (ii) Biological: natural aloe vera; (iii) Biological: aloe vera soup	Study type: interventional; Phase: not applicable; Study design: (i) Allocation: randomized; (ii) Intervention model: crossover assignment; (iii) Masking: double (participant, investigator); (iv) Primary purpose: treatment; Outcome measures: (v) Change in creatine kinase activity in plasma; (vi) Change in performance of knee extensor muscles; (vii) Change in delayed onset of muscle soreness	NCT03934762
2.	Describing Chinese herbal medicine telehealth care for symptoms related to infectious diseases such as COVID-19	Recruiting	(i) Coronavirus infection	(i) Dietary supplement: Chinese herbal medicine	Study type: observational; Phase: study design: (i) Observational model: ecologic or community; (ii) Time perspective: prospective; Outcome measures: (iii) Patient reported main complaint; (iv) Conduct qualitative analyses of data	NCT04380870
3.	PB125, osteoarthritis, pain, mobility, and energetics	Recruiting	(i) Osteoarthritis, knee; (ii) Muscle weakness; (iii) Pain, joint	(i) Dietary supplement: PB125; (ii) Dietary supplement: placebo	Study type: interventional; Phase: not applicable; Study design: (i) Allocation: nonrandomized; (ii) Intervention model: single group assignment; (iii) Masking: double (participant, outcomes assessor); (iv) Primary purpose: treatment; Outcome measures: (v) Mobility-6 min self-paced walk; (vi) Mobility-sit to stand; (vii) Mobility-static balance; (viii) Mobility-6 min fast-paced walk; (ix) Intermittent and constant knee pain; (x) Energetics-submaximal oxygen consumption; (xi) Energetics-maximal oxygen consumption; (xii) Energetics-hydrogen peroxide emission; (xiii) Bone mineral density; (xiv) Knee range of motion; (xv) Leg extensor strength	NCT04638387