Inhibition of the NLRP3 Inflammasome by a Quercus Serrata Extract and Isolation of the Component Compounds for the Treatment of Arthritis

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Compound</td><td class="align_left">IC<sub>50</sub> (<i>μ</i>M)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Caffeic acid (1)</td><td class="align_left">53.99 ± 1.91</td></tr><tr><td class="align_left">Myricetin-3-O-cellobioside (2)</td><td class="align_left">103.35 ± 2.55</td></tr><tr><td class="align_left">Phloroglucinol (3)</td><td class="align_left">71.98 ± 2.92</td></tr><tr><td class="align_left">(S)-2,3-HHDP-D-glucopyranoside (4)</td><td class="align_left">56.19 ± 4.18</td></tr><tr><td class="align_left">Pedunculagin (5)</td><td class="align_left">24.18 ± 1.06</td></tr><tr><td class="align_left">Ascorbic acid</td><td class="align_left">51.07 ± 1.47</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>IC<sub>50</sub> values of compounds 1–5 and ascorbic acid in the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging assay.</div>

Evidence-Based Complementary and Alternative Medicine

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Table 4

Table 4: Inhibition of the NLRP3 Inflammasome by a Quercus Serrata Extract and Isolation of the Component Compounds for the Treatment of Arthritis 