Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root of Solanum incanum Linnaeus (Solanaceae) in Mice

Table 5

Antihyperglycemic activity of repeated daily doses of Solanum incanum L. root hydro-methanolic extract in STZ-induced diabetic mice.

Group	Baseline	Fasting blood glucose level (mg/dl)		Percentage (%) reduction
		7^th day	14^th day	7^th day	14^th day
DC	293.17 ± 1.76^n3	295.50 ± 0.86^n3	292.18 ± 1.25^n3	−0.8%	0.3%
SIRE100	291.00 ± 0.98^n3	281.85 ± 0.80^n3	273.55 ± 1.20^a1n3	3.1%	6.0%
SIRE200	289.12 ± 1.18^n3	266.82 ± 1.88^a2n3	253.13 ± 1.10^a2n3	7.7%	12.4%
SIRE 400	290.17 ± 2.80^n3	251.42 ± 1.20^a3n3	233.06 ± 1.37^a3n3	13.3%	19.7%
GLC5	287.12 ± 2.02^n3	201.06 ± 1.34^a3n3	190.32 ± 1.93^a3n3	30.0%	33.7%
NC	123.09 ± 1.74^a3	121.51 ± 1.92^a3	124.23 ± 1.41^a3	1.3%	−0.9%

Results are expressed as mean ± SEM (n = 6) and analyzed by one-way ANOVA followed by Tukey’s post hoc test. ^a Compared with negative control, and ⁿ compared with normal control. ¹, ², and ³. SIRE = Solanum incanum root extract, DC = diabetic control, NC = normal control, and GLC = glibenclamide.