Comparative Pharmacokinetics of Seven Major Compounds in Normal and Atherosclerosis Mice after Oral Administration of Simiao Yong’an Decoction

Table 6

Main pharmacokinetic parameters of the seven compounds in mouse plasma after oral administration of SMYAD (mean ± SD, n = 5).

Compounds	Group	Parameters
		t1/2/h	tmax/h	Cmax/ng·mL^−1	AUC0–t/ng·mL^−1·h	AUC0–∞/ng·mL^−1·h	Vz/F (L/mg)	CLz/F (L/h/mg)
Harpagide	NC	8.40 ± 1.80	6.00 ± 2.19	838.40 ± 126.54	6936.17 ± 533.23	7194.33 ± 588.34	32.74 ± 7.64	4.90 ± 0.40
	AS	8.55 ± 3.97	4.00 ± 0.00	939.74 ± 180.83	11075.09 ± 2132.38	16221.95 ± 5622.42	24.34 ± 16.57	2.45 ± 0.87
Chlorogenic acid	NC	4.51 ± 1.10	1.13 ± 0.88	266.84 ± 72.39	1109.84 ± 418.97	1257.70 ± 424.87	247.01 ± 150.71	30.37 ± 7.58
	AS	21.59 ± 9.16	0.25 ± 0.00	1128.91 ± 969.58	1560.11 ± 476.37	2637.51 ± 322.54	302.49 ± 211.89	13.49 ± 1.81
Swertiamarin	NC	4.43 ± 2.06	5.00 ± 4.97	1431.10 ± 636.23	5349.68 ± 1183.98	5401.77 ± 1243.88	20.82 ± 11.26	5.82 ± 2.64
	AS	5.74 ± 1.90	0.90 ± 0.64	1335.08 ± 603.03	5542.40 ± 2011.02	7243.79 ± 3391.00	55.16 ± 45.04	5.70 ± 1.93
Sweroside	NC	3.81 ± 0.56	0.40 ± 0.30	1793.48 ± 368.69	6983.11 ± 381.87	7083.75 ± 389.99	16.99 ± 3.78	4.96 ± 0.28
	AS	6.56 ± 2.75	0.90 ± 0.64	1588.23 ± 496.61	7501.27 ± 1799.94	8926.84 ± 2117.67	29.99 ± 14.26	4.29 ± 1.55
Angoroside C	NC	7.40 ± 4.76	0.85 ± 0.62	288.62 ± 123.79	1732.42 ± 882.96	1865.70 ± 1053.21	148.22 ± 76.23	29.75 ± 24.10
	AS	7.33 ± 4.68	2.05 ± 1.19	491.04 ± 238.94	1838.19 ± 298.23	1891.33 ± 226.37	126.00 ± 102.72	18.79 ± 2.39
Liquiritin	NC	16.98 ± 3.43	0.75 ± 0.63	132.03 ± 57.09	606.62 ± 229.46	760.40 ± 333.88	565.81 ± 116.60	58.74 ± 30.94
	AS	13.54 ± 3.57	0.75 ± 0.69	67.62 ± 33.62	407.58 ± 115.29	481.57 ± 137.03	887.57 ± 397.82	67.62 ± 33.62
Isoliquiritigenin	NC	6.65 ± 1.31	1.90 ± 2.13	175.33 ± 49.02	1036.28 ± 144.06	1063.27 ± 144.39	198.37 ± 58.53	33.51 ± 4.41
	AS	6.01 ± 2.32	0.95 ± 0.60	134.59 ± 101.80	502.25 ± 165.65	653.68 ± 251.34	658.87 ± 555.51	62.16 ± 23.35

Compared with the NC group, , .