Study on the Potential Molecular Mechanism of Xihuang Pill in the Treatment of Pancreatic Cancer Based on Network Pharmacology and Bioinformatics

Table 2

Key targets.

Name	Closeness centrality	Degree	Betweenness centrality
TP53	0.85	42	0.068810131
VEGFA	0.836065574	41	0.056756149
IL6	0.796875	38	0.05317606
MAPK1	0.796875	38	0.043544924
EGF	0.784615385	37	0.037239889
EGFR	0.784615385	37	0.043334685
JUN	0.76119403	35	0.022646029
MAPK8	0.76119403	35	0.024236994
TNF	0.739130435	33	0.01515152
ESR1	0.739130435	33	0.043118785
PTGS2	0.739130435	33	0.013562229
IL1B	0.728571429	32	0.012370454
MMP2	0.718309859	31	0.010559301
MAPK14	0.708333333	30	0.012303754
CAT	0.698630137	30	0.05575807
CCL2	0.708333333	30	0.007732274
MMP1	0.662337662	26	0.017930964
MMP3	0.662337662	26	0.016948756
MPO	0.671052632	26	0.016875167
IFNG	0.671052632	26	0.006005576
NGF	0.662337662	25	0.006541835
IL2	0.662337662	25	0.00545143
CXCL12	0.653846154	25	0.004267719
CXCR4	0.6375	23	0.003965538
HMOX1	0.64556962	23	0.00604897
PLAU	0.62195122	21	0.001768495
NOS2	0.593023256	17	7.63E-04