Review Article

Efficacy and Safety of “Three Chinese Patent Medicines and Three TCM Prescriptions” for COVID-19: A Systematic Review and Network Meta-Analysis

Table 1

Characteristics of the 18 trials included in the Bayesian network meta-analysis.

Author(s)Sample size (experimental/control)Time frame (y)Contrast drugsDurationOutcome measures

Chen et al. (2020)15/152020.1–2020.3XBJ vs. CD14 daysClinical effect, CRP, adverse reactions.
Cheng et al. (2020)51/512020.1.1–2020.1.30LHQW vs. CD7 daysCT, fever, cough, fatigue, expectoration, shortness of breath, chest distress, nausea, inappetence, muscle soreness, exacerbation rate.
Duan et al. (2020)82/412020.2.1–2020.2.5JHQG vs. CD5 daysFever, cough, fatigue, expectoration, rhinobyon, rhinorrhea, sore throat, nausea, diarrhea, emesis, muscle soreness, exacerbation rate, adverse reactions.
Fang et al. (2020)42/412020.1.28–2020.3.31LHQW vs. CDNRFever, cough, expectoration, shortness of breath, rhinobyon, rhinorrhea, muscle soreness.
Guo et al. (2020)16/162020.1.20–2020.3.11XBJ vs. CDNRCT, fever, cough, fatigue, expectoration, diarrhea, CRP, WBC.
Hu et al. (2020)142/1422020.2.2–2020.2.15LHQW vs. CD14 daysClinical effect, CT, exacerbation rate, adverse reactions.
Li and Zhang (2020)6/62020.2–2020.3QFPD vs. CD6 daysClinical effect, WBC, adverse reactions.
Li et al. (2020)30/302020.1.24–2020.3.7QFPD vs. CDNRClinical effect, exacerbation rate, adverse reactions.
Luo et al. (2021)29/282020.2.16–2020.3.25XBJ vs. CD14 daysExacerbation rate, adverse reactions.
Lv et al. (2020)63/382020.1.1–2020.1.27LHQW vs. CD10 daysFever, cough, fatigue, expectoration, shortness of breath, chest distress, rhinobyon, rhinorrhea, sore throat, nausea, diarrhea, emesis, inappetence, muscle soreness, headache, exacerbation rate, adverse reactions.
Wen et al. (2020)20/202020.1–2020.3XBJ vs. CD7 daysNANR, CRP, WBC, exacerbation rate.
Xiong et al. (2020)22/202020.1.30–2020.2.10XFBD vs. CD7 daysFever, cough, fatigue, shortness of breath, chest distress, sore throat, nausea, diarrhea, emesis, inappetence, headache.
Xu et al. (2020)26/262020.1.29–2020.2.28LHQW vs. CD7 daysCT.
Yao et al. (2020)21/212020.1.11–1.30LHQW vs. CDNRFever, cough, fatigue, expectoration, shortness of breath, chest distress, rhinobyon, rhinorrhea, sore throat, nausea, diarrhea, emesis, inappetence, muscle soreness, headache.
Yu et al. (2020)147/1482020.2.17–2020.3.6LHQW vs. CD7 daysClinical effect, CT, CRP, exacerbation rate.
Zeng et al. (2020)104/1252019.12–2020.3QFPD vs. CDNRCT, adverse reactions.
Zhang et al. (2020)22/222020.1.21–2020.2.24XBJ vs. CD7 daysClinical effect, CT, NANR, adverse reactions.
Zhao et al. (2021)204/2042020.2.13–3.7HSBD vs. CD7 daysExacerbation rate.

Abbreviations: CD, chemical drugs; CRP, C-reactive protein; HSBD, Hua-Shi-Bai-Du; JHQG, Jin-Hua-Qing-Gan; LHQW, Lian-Hua-Qing-Wen; NANR, nucleic acid negative rate; NR, not reported; QDPD, Qing-Fei-Pai-Du; WBC, white blood cell; XBJ, Xue-Bi-Jing; XFBD, Xuan-Fei- Bai-Du.