Exploring the Effect and Mechanism of Si-Miao-Yong-An Decoction on Abdominal Aortic Aneurysm Based on Mice Experiment and Bioinformatics Analysis

Figure 2

SMYAD inhibited Bap/Ang II-induced inflammatory response in mice. ((a) ×20) Representative photomicrographs of immunohistochemistry staining with macrophage CD68 antibody of abdominal aortic sections from four groups. Brown or dark brown staining in cytoplasm was defined as positive expression. Scale bar 20 μm. (b) Quantification of macrophage infiltration in abdominal aortic sections. Data represented the mean ± SD. vs control, vs Bap + Ang II, vs Bap + Ang II + SH. (c) There was a positive correlation between circulating interleukin-6 (IL-6) levels and abdominal aortic perimeters (r = 0.81, ). (d) Quantification of circulating IL-6 levels at Day 1 and Day 43. Data represented the mean ± SD. vs control, vs Bap + Ang II, vs Bap + Ang II + SH.

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