Exploring the Effect and Mechanism of Si-Miao-Yong-An Decoction on Abdominal Aortic Aneurysm Based on Mice Experiment and Bioinformatics Analysis

<div>Network pharmacology-based elucidations of mechanisms of SMYAD on AAA. (a) Interaction network of SMYAD-target-biological process (BP)-Kyoto Encyclopedia of Genes and Genomes (KEGG)-AAA. The orange nodes represented the common targets of SYMAD and AAA, and the enriched BP and KEGG pathways related to inflammation and elastin lamella were selected out of top 20 <i>q</i>-value entries. (b) Protein-protein interaction (PPI) network was generated from string database and visualized by Cytoscape (sorted by nodes degree and edges combined score). (c) PPI network was analyzed by the CytoHubb algorithms, and the top six targets in MCC score were identified as hub targets of SMYAD against AAA.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 4: Exploring the Effect and Mechanism of Si-Miao-Yong-An Decoction on Abdominal Aortic Aneurysm Based on Mice Experiment and Bioinformatics Analysis 

Figure 4 | Exploring the Effect and Mechanism of Si-Miao-Yong-An Decoction on Abdominal Aortic Aneurysm Based on Mice Experiment and Bioinformatics Analysis 