Botanical from the Fruits Mesocarp of Raphia vinifera Displays Antiproliferative Activity and Is Harmless as Evidenced by Toxicological Assessments

Figure 4

(a). Effect of RVM on liver histopathology in female rats during subchronic toxicity study: (L₀): control group; (L₁): 250 mg/kg; (L₂): 500 mg/kg; and (L₃): 1000 mg/kg. Indicators: (Cb): bile duct; (VPH): hepatic portal vein; (H): hepatocytes; (S): sinusoid. (b) Effect of RVM on liver histopathology in male rats during subchronic toxicity study: (L₀): control group; (L₁): 250 mg/kg; (L₂): 500 mg/kg; and (L₃): 1000 mg/kg. Indicators: (VPH): hepatic portal vein; (H): hepatocytes; and (S): sinusoid. The liver photomicrographs presented in the document represent the general appearance observed in at least three of four animals in each group.

(a)

(b)