Botanical from the Fruits Mesocarp of Raphia vinifera Displays Antiproliferative Activity and Is Harmless as Evidenced by Toxicological Assessments

Table 10

Effect of RVM on hematological parameters of the rats treated with RVM during subchronic toxicity study.

Sexes	Parameters	Control	Extract doses (mg/kg)
			250	500	1000
Females	WBCs (×10^3 /µl)	4.60 ± 0.36^a	5.03 ± 0.72^a	4.25 ± 0.65^a	7.30 ± 0.87^b
	Lymph (%)	64.00 ± 4.90^a	65.93 ± 5.66^a	63.88 ± 3.63^a	63.87 ± 3.62^a
	MONO (%)	6.27 ± 0.40^b	6.23 ± 0.18^b	5.75 ± 0.15^b	4.27 ± 0.97^a
	GR (%)	29.73 ± 4.51^a	28.20 ± 1.23^a	30.45 ± 3.55^a	31.87 ± 2.26^a
	PLT (×10^3/µl)	847.00 ± 7.94^a	855.00 ± 6.00^a	850.00 ± 2.00^a	871.50 ± 5.50^b
	MPV (fL)	6.77 ± 0.12^a	6.97 ± 0.31^a	6.87 ± 0.40^a	6.90 ± 0.20^a
	RBCs (×10^6/µl)	8.88 ± 0.01^a	8.55 ± 0.15^a	8.48 ± 0.31^a	8.62 ± 0.16^a
	Hb (g/dL)	18.30 ± 0.66^b	17.47 ± 0.95^a,b	16.70 ± 0.82^a,b	16.50 ± 0.79^a
	HCT (%)	54.43 ± 1.66^b	51.20 ± 2.07^a,b	51.17 ± 0.55^a,b	47.90 ± 3.81^a
	MCV (fL)	60.10 ± 0.78^a	59.90 ± 1.56^a	60.37 ± 2.15^a	60.83 ± 1.12^a
	MCH (pg)	20.23 ± 0.93^a	20.40 ± 0.82^a	19.70 ± 0.20^a	21.00 ± 1.04^a
	MCHC (g/dL)	33.63 ± 1.14^a	34.33 ± 0.55^a	32.70 ± 1.55^a	34.50 ± 1.08^a
Males	WBCs (×10^3/µl)	6.20 ± 1.00^a	6.40 ± 0.26^a	5.55 ± 1.05^a	6.35 ± 0.35^a
	Lymph (%)	69.80 ± 1.91^b	68.57 ± 3.42^b	62.30 ± 3.90^b	51.57 ± 2.43^a
	MONO (%)	4.40 ± 0.66^a	4.53 ± 0.55^a	5.10 ± 0.90^a	5.47 ± 0.32^a
	GR (%)	26.80 ± 0.30^a	26.90 ± 3.60^a	31.10 ± 1.50^a	47.97 ± 4.44^b
	PLT (×10^3/µl)	666.33 ± 10.97^a	662.33 ± 4.51^a	664.00 ± 5.29^a	860.33 ± 17.04^b
	MPV (fL)	6.90 ± 0.00^a	7.43 ± 0.23^a	7.10 ± 0.20^a	6.90 ± 1.00^a
	RBCs (×10^6/µl)	9.11 ± 0.67^a	8.67 ± 0.44^a	9.21 ± 0.65^a	9.55 ± 0.50^a
	Hb (g/dL)	17.53 ± 0.12^a	17.20 ± 0.85^a	18.05 ± 1.05^a	17.83 ± 1.47^a
	HCT (%)	54.57 ± 2.94^a	53.50 ± 1.00^a	56.67 ± 1.14^a	56.63 ± 4.29^a
	MCV (fL)	59.97 ± 2.03^a	60.53 ± 0.76^a	61.70 ± 3.75^a	59.27 ± 2.57^a
	MCH (pg)	19.30 ± 1.56^a	19.87 ± 0.06^a	20.03 ± 0.76^a	18.67 ± 0.85^a
	MCHC (g/dL)	32.17 ± 1.91^a	32.80 ± 0.35^a	32.50 ± 0.82^a	31.50 ± 0.30^a

The table values are presented as mean ± standard deviation of 4 repetitions. In the same line and by sex, the values bearing the different letters are significantly different according to Waller Duncan’s multiple comparison test (). Indication: WBCs: white blood cells, Lymph: lymphocytes, Mono: monocytes, GR: granulocytes, PLT: platelets, MPV: mean platelet volume, RBCs: red blood cells, Hb: hemoglobin, HCT: hematocrit, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration.