Research Article
Botanical from the Fruits Mesocarp of Raphia vinifera Displays Antiproliferative Activity and Is Harmless as Evidenced by Toxicological Assessments
Table 2
Cytotoxicity of RVM and doxorubicin against drug-sensitive cell lines, their resistant counterparts, and normal hepatocytes as determined by RRA.
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(): The degree of resistance was determined as the ratio of IC50 value in the resistant divided by the IC50 in the sensitive cell line; CEM/ADR5000, MDA-MB-231-BCRP, HCT116 p53−/−, and U87MG.ΔEGFR were used as the corresponding resistant counterpart for CCRF-CEM, MDA-MB-231-pc DNA, HCT116 p53+/+, and U87MG cell lines, respectively; (): The selectivity index was determined as the ratio of IC50 value in the normal AML12 hepatocytes divided by the IC50 in HepG2 hepatocarcinoma cells; nd: not determined. |