Botanical from the Fruits Mesocarp of Raphia vinifera Displays Antiproliferative Activity and Is Harmless as Evidenced by Toxicological Assessments
Table 6
Effect of RVM on organ weights (g) of the rats during subchronic toxicity study.
Sexes
Organs (g)
Control
Extract doses (mg/kg)
250
500
1000
Female
Liver
3.12 ± 0.16a
2.91 ± 0.17a
2.93 ± 0.16a
3.06 ± 0.28a
Kidneys
0.65 ± 0.02a,b
0.68 ± 0.04a
0.61 ± 0.05b
0.69 ± 0.03a
Lung
0.57 ± 0.04a
0.54 ± 0.04a
0.54 ± 0.03a
0.66 ± 0.26a
Heart
0.30 ± 0.01a,b
0.29 ± 0.01a;b
0.27 ± 0.01a
0.32 ± 0.01a
Spleen
0.20 ± 0.02a
0.36 ± 0.15a
0.26 ± 0.12a
0.30 ± 0.08a
Male
Liver
3.39 ± 0.44a
3.16 ± 0.57a
3.23 ± 0.31a
3.06 ± 0.15a
Kidneys
0.65 ± 0.05a
0.65 ± 0.05a
0.65 ± 0.10a
0.58 ± 0.04a
Lung
0.59 ± 0.12a
0.65 ± 0.05a
0.52 ± 0.04a
0.53 ± 0.06a
Heart
0.32 ± 0.04a
0.31 ± 0.01a
0.30 ± 0.01a
0.31 ± 0.01a
Spleen
0.35 ± 0.09b
0.40 ± 0.09b
0.30 ± 0.10a,b
0.20 ± 0.01a
The table values are presented as mean ± standard deviation of 4 repetitions. In the same line and by sex, the values bearing the different letters are significantly different according to Waller Duncan’s multiple comparison test ().