Botanical from the Fruits Mesocarp of Raphia vinifera Displays Antiproliferative Activity and Is Harmless as Evidenced by Toxicological Assessments

Table 6

Effect of RVM on organ weights (g) of the rats during subchronic toxicity study.

Sexes	Organs (g)	Control	Extract doses (mg/kg)
			250	500	1000
Female	Liver	3.12 ± 0.16^a	2.91 ± 0.17^a	2.93 ± 0.16^a	3.06 ± 0.28^a
	Kidneys	0.65 ± 0.02^a,b	0.68 ± 0.04^a	0.61 ± 0.05^b	0.69 ± 0.03^a
	Lung	0.57 ± 0.04^a	0.54 ± 0.04^a	0.54 ± 0.03^a	0.66 ± 0.26^a
	Heart	0.30 ± 0.01^a,b	0.29 ± 0.01^a;b	0.27 ± 0.01^a	0.32 ± 0.01^a
	Spleen	0.20 ± 0.02^a	0.36 ± 0.15^a	0.26 ± 0.12^a	0.30 ± 0.08^a
Male	Liver	3.39 ± 0.44^a	3.16 ± 0.57^a	3.23 ± 0.31^a	3.06 ± 0.15^a
	Kidneys	0.65 ± 0.05^a	0.65 ± 0.05^a	0.65 ± 0.10^a	0.58 ± 0.04^a
	Lung	0.59 ± 0.12^a	0.65 ± 0.05^a	0.52 ± 0.04^a	0.53 ± 0.06^a
	Heart	0.32 ± 0.04^a	0.31 ± 0.01^a	0.30 ± 0.01^a	0.31 ± 0.01^a
	Spleen	0.35 ± 0.09^b	0.40 ± 0.09^b	0.30 ± 0.10^a,b	0.20 ± 0.01^a

The table values are presented as mean ± standard deviation of 4 repetitions. In the same line and by sex, the values bearing the different letters are significantly different according to Waller Duncan’s multiple comparison test ().