Network Pharmacology and Experimental Validation to Reveal Effects and Mechanisms of Icariin Combined with Nobiletin against Chronic Obstructive Pulmonary Diseases

Table 1

Binding energy between components and 7 highest scoring targets (kcal/mol).

Components	CID	Targets	PDB ID	Binding energy
Icariin	5318997	AKT	2UZR	−4.38
Icariin	5318997	EGFR	5Y9T	−5.84
Icariin	5318997	MMP9	1L6J	−5.32
Icariin	5318997	JUN	5T01	−3.25
Icariin	5318997	SRC	2BDF	−2.95
Icariin	5318997	TNF	7KP9	−4.28
Nobiletin	72344	AKT	2UZR	−5.36
Nobiletin	72344	EGFR	5Y9T	−5.85
Nobiletin	72344	MMP9	1L6J	−6.2
Nobiletin	72344	SRC	2BDF	−6.18
Nobiletin	72344	VEGFA	7LL8	−5.84