Evaluation of Ulcer Protective Activity of Morus alba L. Extract-Loaded Chitosan Microspheres in Ethanol-Induced Ulcer in Rat Model

Figure 10

Therapeutic impact of M. alba on the lining of the stomach in rats with stomach mucosal damage caused by ethanol. By boosting the stomach mucosa’s defensive function, M. alba assisted in the recovery of damaged histology. (a) Normal control rats, (b) ethanol-treated rats with profound necrosis and extensive mucosal injury (orange arrow) (black arrow), (c) omeprazole (20 mg/kg + ethanol), (d) ME (500 mg/kg)+ETH, and (e) MEM (equivalent to 500 mg/kg)+ETH showed a potent gastroprotective implication, as evidenced by reduced mucosal aberration, gastric epithelial necrosis, and inflammatory cell infiltration, as well as restoration of the mucosal barrier (blue arrow).

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