Research Article
Evaluation of Ulcer Protective Activity of Morus alba L. Extract-Loaded Chitosan Microspheres in Ethanol-Induced Ulcer in Rat Model
Table 2
Various runs at different experimental conditions are suggested by the Box-Behnken design.
| Run | Independent variables | Responses | Chitosan (A) | Glutaraldehyde (B) | RPM (C) | Y 1 (% yield) | Y 2a (%EE for rutin) | Y 2b (%EE for quercetin) | Particle size (µm) |
| R1 | 1 | 1 | 1000 | 84.14 | 71.82 | 70.23 | 45.25 | R2 | 2 | 1 | 1000 | 86.36 | 76.54 | 74.34 | 51.67 | R3 | 1 | 5 | 1000 | 86.28 | 77.14 | 74.13 | 41.27 | R4 | 2 | 5 | 1000 | 88.22 | 79.43 | 76.76 | 45.07 | R5 | 1 | 3 | 800 | 95.85 | 85.45 | 83.11 | 40.48 | R6 | 2 | 3 | 800 | 93.88 | 89.33 | 87.43 | 46.29 | R7 | 1 | 3 | 1200 | 79.42 | 76.23 | 74.87 | 39.98 | R8 | 2 | 3 | 1200 | 85.77 | 80.54 | 77.11 | 43.61 | R9 | 1.5 | 1 | 800 | 96.5 | 88.34 | 84.98 | 44.48 | R10 | 1.5 | 5 | 800 | 98.3 | 91.66 | 88.24 | 38.33 | R11 | 1.5 | 1 | 1200 | 83.5 | 78.11 | 76.89 | 42.46 | R12 | 1.5 | 5 | 1200 | 85.37 | 82.34 | 79.11 | 38.24 | R13 | 1.5 | 3 | 1000 | 90.1 | 80.59 | 77.89 | 40.03 | R14 | 1.5 | 3 | 1000 | 90.5 | 79.29 | 77.02 | 39.27 | R15 | 1.5 | 3 | 1000 | 90.2 | 81.87 | 78.45 | 40.86 | R16 | 1.5 | 3 | 1000 | 91.01 | 80.82 | 78.1 | 40.36 | R17 | 1.5 | 3 | 1000 | 89.8 | 79.23 | 77.32 | 39.24 |
|
|