Evaluation of Ulcer Protective Activity of Morus alba L. Extract-Loaded Chitosan Microspheres in Ethanol-Induced Ulcer in Rat Model

Table 2

Various runs at different experimental conditions are suggested by the Box-Behnken design.

Run	Independent variables			Responses
	Chitosan (A)	Glutaraldehyde (B)	RPM (C)	Y 1 (% yield)	Y 2a (%EE for rutin)	Y 2b (%EE for quercetin)	Particle size (µm)
R1	1	1	1000	84.14	71.82	70.23	45.25
R2	2	1	1000	86.36	76.54	74.34	51.67
R3	1	5	1000	86.28	77.14	74.13	41.27
R4	2	5	1000	88.22	79.43	76.76	45.07
R5	1	3	800	95.85	85.45	83.11	40.48
R6	2	3	800	93.88	89.33	87.43	46.29
R7	1	3	1200	79.42	76.23	74.87	39.98
R8	2	3	1200	85.77	80.54	77.11	43.61
R9	1.5	1	800	96.5	88.34	84.98	44.48
R10	1.5	5	800	98.3	91.66	88.24	38.33
R11	1.5	1	1200	83.5	78.11	76.89	42.46
R12	1.5	5	1200	85.37	82.34	79.11	38.24
R13	1.5	3	1000	90.1	80.59	77.89	40.03
R14	1.5	3	1000	90.5	79.29	77.02	39.27
R15	1.5	3	1000	90.2	81.87	78.45	40.86
R16	1.5	3	1000	91.01	80.82	78.1	40.36
R17	1.5	3	1000	89.8	79.23	77.32	39.24