Exploring the Ferroptosis Mechanism of Zhilong Huoxue Tongyu Capsule for the Treatment of Intracerebral Hemorrhage Based on Network Pharmacology and In Vivo Validation

Figure 2

(a) Venn diagram of 33 intersecting targets among ZL capsule, ICH and ferroptosis. Green represents the 249 intersecting targets between ICH and ferroptosis, blue represents the 40 intersecting targets between ZL capsule and ferroptosis, red represents the 300 intersecting targets between ZL capsule and ICH. The overlapping area reprents 33 intersecting targets among them. (b) The 33 intersecting targets of PPI network diagram among ZL capsule, ICH and ferroptosis. The size of circulars represents the importance of related gene target according to the degree value. The larger circular size, the more important the pathway is. The thicker the line between two targets, the closer the relationship between the two targets is. (c) The active ingredients-targets diagram of ZL capsule. Diamond reprents gene targets, triangle represents related TCM, circular reprents active ingredients, and the same color of circulars mean they are from the same TCM. Additionally, A & B are re-duplicate ingredients between Guizhi and Daxueteng, so we list them separately.

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