Research Article

Exploring the Ferroptosis Mechanism of Zhilong Huoxue Tongyu Capsule for the Treatment of Intracerebral Hemorrhage Based on Network Pharmacology and In Vivo Validation

Table 4

Top 11 related pathways in metascape for the ICH treatment of ZL capsule via ferroptosis.

GODescriptionCount%Log10 ()Log10 (q)Hits

hsa05200Pathways in cancer1751.52−20.99−18.57CASP8, NQO1, EGFR, GSK3B, GSTP1, HMOX1, JUN, MYC, NFE2L2, MAPK1, PTEN, PTGS2, RB1, RELA, TGFB1, TGFB2, TP53
hsa05161Hepatitis B1030.3−14.91−12.85CASP8, JUN, MYC, MAPK1, RB1, RELA, TGFB1, TGFB2, TNF, TP53
hsa05163Human cytomegalovirus infection1030.3−13.47−11.63CASP8, EGFR, GSK3B, MYC, MAPK1, PTGS2, RB1, RELA, TNF, TP53
hsa04657IL-17 signaling pathway824.24−13.07−11.44CASP8, GSK3B, JUN, MAPK1, PTGS2, RELA, TNF, TNFAIP3
hsa05418Fluid shear stress and atherosclerosis824.24−11.69−10.39NQO1, GSTP1, HMOX1, JUN, NFE2L2, RELA, TNF, TP53
hsa05208Chemical carcinogenesis - reactive oxygen species824.24−10.04−8.9NQO1, EGFR, HMOX1, JUN, NFE2L2, MAPK1, PTEN, RELA
hsa04216Ferroptosis515.15−9.08−7.99ALOX15, ACSL4, HMOX1, SLC3A2, TP53
hsa01524Platinum drug resistance412.12−5.91−5.22CASP8, GSTP1, MAPK1, TP53
hsa05012Parkinson disease515.15−5−4.39HSPA5, NFE2L2, SNCA, TP53, UCHL1
hsa04217Necroptosis412.12−4.57−3.98ALOX15, CASP8, TNF, TNFAIP3
hsa04370VEGF signaling pathway39.09−4.43−3.86HSPB1, MAPK1, PTGS2