Therapeutic Investigation of Standardized Aqueous Methanolic Extract of Bitter Melon (Momordica charantia L.) for Its Potential against Polycystic Ovarian Syndrome in Experimental Animals’ Model: In Vitro and In Vivo Studies

Figure 4

Effect of aqueous methanolic extract of bitter melon (Momordica charantia L.) on ovarian tissues of PCOS induced female rats’ model. Ovarian cross section stained by Hematoxylin-Eosin stain. (a) The control group showing the atretic follicle, corpus luteum, developing and primary follicle and oocyte (b) The PCOS group showing cystic and atretic follicles. (c) The bitter melon group can be observed with the follicles of various stages present such as atretic follicle, corpus luteum, developing and the primary follicle. (d) The combination group also showed atretic follicle, corpus luteum, developing follicles and the granulosa cells. (e) The metformin group is showed the presence of developing, atretic follicles, granulosa cells, primary follicle and corpus luteum. CL : Corpus luteum, Oo: oocyte, CF : Cystic follicles, AF: atretic follicles, DF: developing follicles, PF: primary follicles, GC: granulosa cells. Scale bar is equal to 100 µM. Magnification 4×.

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