Therapeutic Investigation of Standardized Aqueous Methanolic Extract of Bitter Melon (Momordica charantia L.) for Its Potential against Polycystic Ovarian Syndrome in Experimental Animals’ Model: In Vitro and In Vivo Studies

Table 1

Experimental design and dosage schedule.

Groups	Treatment protocols
Normal control (NC) or control	Aqueous solution of carboxyl methylcellulose CMC 0.5% solution (10 mL/kg/day, p.o.)
Disease induced (PCOS)	Letrozole (1 mg/kg/day, p.o.) dissolved in CMC solution
Aqueous methanolic extract of bitter melon group (Momordica charantia L.)	Bitter melon extract (500 mg/kg/day, p.o.) dissolved in CMC solution
Bitter melon plus metformin) (combination group)	Bitter melon extract (500 mg/kg/day, p.o.) + metformin (500 mg/kg/day p.o.) dissolved in CMC solution
Metformin group	Metformin (20 mg/kg/day p.o.) dissolved in CMC solution