GOLM1 as a Potential Therapeutic Target Modulates B7-H3 Secretion to Drive Ovarian Cancer Metastasis

Figure 1

GOLM1 is correlated with B7-H3 expression in human ovarian cancer. (a) The mRNA expression of GOLM1 and B7-H3 was analyzed with the Pearson Correlation analysis GEPIA database |Log2FC| cutoff = 1; q-value cutoff = 0.01; ANOVA differential analysis in 426 ovarian cancer (OV) samples and 88 normal ovarian tissue. (b) The GOLM1 and B7-H3 mRNA levels were retrieved from OV dataset (n = 379) with ENCORI database, R = 0.421. (c) IHC plot of the typical protein expression of GOLM1 and B7-H3 in two OV patients (ID: 1884 and 2347) from The Human Protein Atlas. (d) Statistical analysis of GOLM1 and B7-H3 protein expression in 12 patients from patients with OV from The Human Protein Atlas. (e) Kaplan–Meier plot of the overall survival of 1402 ovarian cancer patients in TCGA database. The logrank value was 0.0016.

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