Antidiabetic Potential and Antioxidant Activity of Olea europaea subsp. Cuspidata (Indian Olive) Seed Extracts
Table 2
Effect of methanolic and aqueous extracts of Olea europaea subsp. Cuspidata seeds on the liver and kidney function tests in diabetic rats.
Parameters
Normal control
Diabetic control
Standard therapy
Aqueous extract (mg/kg/day)
Methanolic extract (mg/kg/day)
250
500
750
250
500
750
Alanine aminotransferase (U/L)
49 ± 6.47
167 ± 6.15
55 ± 1.25
61 ± 3.35
50 ± 4.32
37 ± 2.10#
60 ± 5.3
53 ± 4.23
42 ± 5.36
Aspartate aminotransferase (U/L)
106 ± 4.16
165 ± 4.23
105 ± 6.02
141 ± 5.48
130 ± 6.54
104 ± 5.36
156 ± 5.61
136 ± 4.36
135 ± 1.47
Alkaline phosphatase (U/L)
142 ± 5.01
388 ± 5.02
251 ± 4.56
193 ± 4.18#
177 ± 5.02#
77 ± 4.35#
189 ± 8.66#
151 ± 6.78#
106 ± 1.62#
Bilirubin total (mg/dl)
0.1 ± 0.05
0.1 ± 0.02
0.1 ± 0.02
0.1 ± 0.03
0.2 ± 0.04
0.1 ± 0.02
0.08 ± 0.001
0.09 ± 0.001
0.1 ± 0.01
Bilirubin direct (mg/dl)
0.01 ± 0.001
0.01 ± 0.001
0.03 ± 0.01
0.02 ± 0.01
0.05 ± 0.01
0.02 ± 0.001
0.2 ± 0.02
0.2 ± 0.01
0.01 ± 0.001
Total protein (g/dl)
6.7 ± 1.24
5.2 ± 0.32
6.1 ± 1.02
6.2 ± 0.22
6.4 ± 0.14
6.8 ± 0.05
5.6 ± 0.44
4.9 ± 0.61
7 ± 0.05
Albumin (g/dl)
4.5 ± 1.01
3.3 ± 0.21
4.6 ± 0.14
4.4 ± 0.01
4.8 ± 0.03
4.8 ± 0.01
4.6 ± 0.12
4.9 ± 0.21
5 ± 0.01
Gama glutamyl transferase (U/L)
0.1 ± 0.04
37 ± 4.21
7 ± 1.54
16 ± 1.26
6.2 ± 0.12
6.2 ± 0.35
6.2 ± 0.02
4.2 ± 0.03
4.1 ± 0.07
Urea (mg/dl)
58 ± 5.61
460 ± 6.58
36 ± 4.25
68 ± 3.60#
57 ± 4.56#
46 ± 1.54
64 ± 3.32#
54 ± 2.13#
48 ± 5.69
Creatinine (mg/dl)
0.4 ± 0.07
5.9 ± 0.32
0.3 ± 0.05
0.3 ± 0.05
0.3 ± 0.04
0.3 ± 0.01
0.9 ± 0.02
0.4 ± 0.05
0.4 ± 0.01
Values were presented as mean with +S.D (n = 6). represents the significant difference with untreated diabetic rats and #shows statistical difference with standard therapy at .
