| | Study | Year | Country | Sample | Age, mean ± SD | Female, n(%) | Follow-up | ClinicalTrials.gov | Acupoints | Intervention | Control | | Acupuncture | Control | Acupuncture | Control |
| | Adly et al. | 2021 | Egypt | 26/34 | 68.8 ± 2.6 | 69.1 ± 2.8 | 18 (60.0) | 23 (76.6) | 4 weeks | NCT04684693 | ST25, LR8, SP6, SP9, and PC6 | Laser acupuncture + aerobic exercise | Aerobic exercise | | Zanette et al. | 2008 | Brazil | 20/20 | 53.1 ± 12.4 | 46.5 ± 9.9 | 17 (85) | 20 (100) | 9 weeks | / | Supine position: EX1, PC6, IG4, EX28, CV12, CV6, ST36, SP6, and LV3; Ventral position: UB20, UB22, UB23, GV4, GV14, UB11, and UB60 | Acupuncture (20 min, 2 times weekly for 5 weeks) plus analgesia | Penetrating sham acupuncture (nonacupoints, minimal, 20 min, 10 times) plus analgesia | | Tam et al. | 2007 | China | 12/12/12 | 56.4 ± 8.5 58.1 ± 12.0 | 57.6 ± 8.3 | 11 (91.7) 10 (83.3) | 8 (66.7) | 10 weeks | NCT00404443 | LI11, TE5, LI4, ST36, GB34, and GB39 | Acupuncture (40 min, 2 times weekly for 10 weeks) plus analgesia | Penetrating sham electroacupuncture plus analgesia | | Seca et al. | 2019 | Portugal | 35/35 | 57.3 ± 11.3 | 56.5 ± 16.4 | 31 (88.6) | 30 (85.7) | 4 weeks | NCT02553005 | TB5, GB39, HT3, and KI7 | Verum acupuncture (2 times weekly for 4 weeks) | Penetrating sham acupuncture (2 times weekly for 4 weeks) | | Adly et al. | 2021 | Egypt | 30/30 | 68.9 ± 2.7 | 69.1 ± 2.9 | 41 (68.3) | 4 weeks | NCT04758689 | ST36, LR8, SP9, and PC6 | Laser acupuncture + aerobic exercise + methotrexate | Aerobic exercise + methotrexate | | | Adly et al. | 2017 | Egypt | 15/15 | 61.9 ± 2.6 | 63.2 ± 3.7 | 22 (73.3) | 4 weeks | / | LR3, ST25, ST36, SI3, SI4, LI4, LI11, SP6, SP9, GB25, GB34, and HT7 | Laser acupuncture (12 sessions over 4 weeks) | Reflexology therapy (12 sessions over 4 weeks) | | | Zukow et al. | 2011 | Poland | 35/32 | 58.1 ± 11.5 | 57.6 ± 9.2 | 33 (94.3) | 32 (91.4) | 22 weeks | / | LI3, LI4, LI10, LI11, TE5, ST36, SP 4, SP6, BL7, BL43, BL56, BL60, BL62, GB34, GB38, GB39, GB41, GV4, GV14, and GV20 | Acupuncture (30-45 min) | Penetrating sham acupuncture (30-45 min) | | Huang et al. | 2018 | China | 81/82 | 48 ± 5 | 49 ± 8 | 64 (79.0) | 63 (76.8) | 4 weeks | / | / | Acupuncture + Zhuang medicine (7 times weekly for 4 weeks) + csDMARDs | csDMARDs | | Wu et al. | 2006 | China | 45/45 | 52 ± 12 | 51 ± 11 | 36 (80.0) | 35 (77.8) | 5 months | / | SJ14, SI9, LI15, LU5, LI11, PC3, SJ4, SI5, LI5, EX-UE9, EX-LE5, LR8, GB33, ST36, GB34, KI3, ST41, BL60, GB40, EX-LE10, and ST7 | Acupuncture (once every other day for 30 m
in) | Methotrexate | | Lv et al. | 2021 | China | 51/49 | 41 ± 14 | 41 ± 14 | 33 (64.7) | 24 (71.4) | 12 weeks | / | RN12, RN10, RN4, RN6, ST24, and ST26 | Bo's abdominal acupuncture (every other day) + Methotrexate | Methotrexate | | Liang et al. | 2012 | China | 40/40 | 40 ± 9 | 38 ± 9 | 31 (77.5) | 32 (80.0) | 4 weeks | / | BL20, BL23, ST36, CV4, Ex-LE10, LI5, PC7, LI11, TE10, LI15, TE14, Ex-LE5, ST41, and Ex-UE9 | Acupuncture (30 min, 5 times weekly for 4 weeks) + Meloxicam + Methotrexate + Leflunomide | Meloxicam + Methotrexate + Leflunomide |
|
|
