Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications

Figure 1

Canonical and noncanonical pathway pyroptosis. Pyroptosis mechanisms include canonical and noncanonical pathways. The left side of (a) shows the canonical pyroptosis pathway, which is caspase-1 dependent; the right side of (b) shows the noncanonical pathway, which is caspase-4/caspase-5/caspase-11 dependent; the cleavage of gasdermin D (GSDMD) (GSDMD-N domain) forms pores on the cell membrane, inducing pyroptosis.