Dl-3-n-Butylphthalide (NBP) Mitigates Muscular Injury Induced by Limb Ischemia/Reperfusion in Mice through the HMGB1/TLR4/NF-κB Pathway

Figure 1

Effect of NBP on pathological change and wet weight/dry weight ratio of skeletal muscle in I/R-injured mice. (a) H&E staining was used to observe the degree of inflammation of muscular tissue in each group of mice (bar = 50 μm); (b) The pathological score in each group of mice was quantified; (c) The wet weight/dry weight ratio of skeletal muscle was calculated to assess the extent of edema in different groups of mice. (d) The level of LDH was measured in muscular homogenates of each group of mice; (e) The level of CK-MB was measured in muscular homogenates of each group of mice. n = 10 for each group. and .

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