Dl-3-n-Butylphthalide (NBP) Mitigates Muscular Injury Induced by Limb Ischemia/Reperfusion in Mice through the HMGB1/TLR4/NF-κB Pathway

Figure 5

In summary, this study dissected out the effect of NBP on the limb I/R injury-driven skeletal muscle damages, and our findings suggested that NBP could protect limbs against I/R injury by inhibiting inflammation responses and oxidative stress via the HMGB1/TLR4/NF-κB pathway.