Research Article

Investigating the Mechanisms of Pollen Typhae in the Treatment of Diabetic Retinopathy Based on Network Pharmacology and Molecular Docking

Table 3

The top 20 signaling pathways with related genes.

TermPathwayGenesP value

hsa05200Pathways in cancerJUN, NOS2, MMP2, PTGER3, PTGS2, MMP9, EGFR, PGF, IGF1R, VEGFA, AR, PIK3CA, MDM2, AGTR1, AKT1, RARB, PPARG, BCL2L1, MAPK34.30E − 11
hsa05205Proteoglycans in cancerSRC, MMP2, ESR1, TNF, MMP9, EGFR, IGF1R, VEGFA, PIK3CA, MDM2, KDR, AKT1, MAPK37.30E − 09
hsa04014Ras signaling pathwayPIK3CA, PLA2G1B, KDR, PLA2G4A, AKT1, EGFR, PGF, BCL2L1, IGF1R, MAPK3, VEGFA2.62E − 06
hsa04151PI3K-Akt signaling pathwayPIK3CA, MDM2, KDR, AKT1, EGFR, PGF, BCL2L1, IGF1R, MCL1, MAPK3, VEGFA1.05E − 04
hsa04510Focal adhesionJUN, PIK3CA, SRC, KDR, AKT1, EGFR, PGF, IGF1R, MAPK3, VEGFA9.89E − 06
hsa04015Rap1 signaling pathwayPIK3CA, CNR1, SRC, KDR, AKT1, EGFR, PGF, IGF1R, MAPK3, VEGFA1.16E − 05
hsa04915Estrogen signaling pathwayJUN, PIK3CA, SRC, MMP2, AKT1, ESR1, MMP9, EGFR, MAPK33.25E − 07
hsa04370VEGF signaling pathwayPIK3CA, SRC, KDR, PLA2G4A, AKT1, PTGS2, MAPK3, VEGFA1.68E − 07
hsa04066HIF-1 signaling pathwayPIK3CA, NOS2, SERPINE1, AKT1, EGFR, IGF1R, MAPK3, VEGFA3.82E − 06
hsa05142Chagas disease (American trypanosomiasis)JUN, ACE, PIK3CA, NOS2, SERPINE1, AKT1, TNF, MAPK36.52E − 06
hsa04668TNF signaling pathwayJUN, PIK3CA, MMP3, AKT1, PTGS2, TNF, MMP9, MAPK37.88E − 06
hsa05202Transcriptional misregulation in cancerIGFBP3, MMP3, MDM2, PPARG, MPO, MMP9, BCL2L1, IGF1R1.39E − 04
hsa05219Bladder cancerSRC, MMP2, MDM2, MMP9, EGFR, MAPK3, VEGFA3.13E − 07
hsa05215Prostate cancerAR, PIK3CA, MDM2, AKT1, EGFR, IGF1R, MAPK32.94E − 05
hsa05161Hepatitis BJUN, PIK3CA, SRC, AKT1, TNF, MMP9, MAPK34.68E − 04
hsa05164Influenza AJUN, PIK3CA, NLRP3, AKT1, PLG, TNF, MAPK30.001220965
hsa04024cAMP signaling pathwayJUN, PIK3CA, PTGER3, PDE4A, AKT1, PPARA, MAPK30.002361912
hsa05206MicroRNAs in cancerABCB1, MDM2, PTGS2, MMP9, EGFR, MCL1, VEGFA0.013841455
hsa05212Pancreatic cancerPIK3CA, AKT1, EGFR, BCL2L1, MAPK3, VEGFA8.07E − 05
hsa05214GliomaPIK3CA, MDM2, AKT1, EGFR, IGF1R, MAPK38.07E − 05