Evidence-Based Complementary and Alternative Medicine

Research Article

Prediction of the Mechanism of Shaoyao Gancao Decoction in the Treatment of Alopecia Areata by Network Pharmacology and Its Preliminary Verification Study

Table 1

Basic information on Shaoyao Gancao decoction (SGD) components.


Mol. ID	Compound ingredient	OB	DL	Herb

MOL001910	11-Alpha,12-alpha-epoxy-3-beta-23-dihydroxy-30-norolean-20-en-28,12-beta-olide	64.77	0.38	Shaoyao
MOL001918	Paeoniflorgenone	87.59	0.37	Shaoyao
MOL001919	(3S,5R,8R,9R,10S,14S)-3,17-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9-hexahydro-1H-cyclopenta[a]phenanthrene-15,16-dione	43.56	0.53	Shaoyao
MOL001921	Lactiflorin	49.12	0.8	Shaoyao
MOL001924	Paeoniflorin	53.87	0.79	Shaoyao
MOL001925	Paeoniflorin_qt	68.18	0.4	Shaoyao
MOL001928	Albiflorin_qt	66.64	0.33	Shaoyao
MOL001930	Benzoyl paeoniflorin	31.27	0.75	Shaoyao
MOL000211	Mairin	55.38	0.78	Shaoyao,Gancao
MOL000358	Beta-sitosterol	36.91	0.75	Shaoyao
MOL000359	Sitosterol	36.91	0.75	Shaoyao,Gancao
MOL000422	Kaempferol	41.88	0.24	Shaoyao,Gancao
MOL000492	(+)-Catechin	54.83	0.24	Shaoyao
MOL001484	Inermine	75.18	0.54	Gancao
MOL001792	DFV	32.76	0.18	Gancao
MOL002311	Glycyrol	90.78	0.67	Gancao
MOL000239	Jaranol	50.83	0.29	Gancao
MOL002565	Medicarpin	49.22	0.34	Gancao
MOL000354	Isorhamnetin	49.6	0.31	Gancao
MOL003656	Lupiwighteone	51.64	0.37	Gancao
MOL003896	7-Methoxy-2-methyl isoflavone	42.56	0.2	Gancao
MOL000392	Formononetin	69.67	0.21	Gancao
MOL000417	Calycosin	47.75	0.24	Gancao
MOL004328	Naringenin	59.29	0.21	Gancao
MOL004805	(2S)-2-[4-Hydroxy-3-(3-methylbut-2-enyl)phenyl]-8,8-dimethyl-2,3-dihydropyrano[2,3-f]chromen-4-one	31.79	0.72	Gancao
MOL004806	Euchrenone	30.29	0.57	Gancao
MOL004808	Glyasperin B	65.22	0.44	Gancao
MOL004810	Glyasperin F	75.84	0.54	Gancao
MOL004811	Glyasperin C	45.56	0.4	Gancao
MOL004814	Isotrifoliol	31.94	0.42	Gancao
MOL004815	(E)-1-(2,4-Dihydroxyphenyl)-3-(2,2-dimethylchromen-6-yl)prop-2-en-1-one	39.62	0.35	Gancao
MOL004820	Kanzonols W	50.48	0.52	Gancao
MOL004824	(2S)-6-(2,4-Dihydroxyphenyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2,3-dihydrofuro[3,2-g]chromen-7-one	60.25	0.63	Gancao
MOL004827	Semilicoisoflavone B	48.78	0.55	Gancao
MOL004828	Glepidotin A	44.72	0.35	Gancao
MOL004829	Glepidotin B	64.46	0.34	Gancao
MOL004833	Phaseolinisoflavan	32.01	0.45	Gancao
MOL004835	Glypallichalcone	61.6	0.19	Gancao
MOL004838	8-(6-Hydroxy-2-benzofuranyl)-2,2-dimethyl-5-chromenol	58.44	0.38	Gancao
MOL004841	Licochalcone B	76.76	0.19	Gancao
MOL004848	Licochalcone G	49.25	0.32	Gancao
MOL004849	3-(2,4-Dihydroxyphenyl)-8-(1,1-dimethylprop-2-enyl)-7-hydroxy-5-methoxy-coumarin	59.62	0.43	Gancao
MOL004855	Licoricone	63.58	0.47	Gancao
MOL004856	Gancaonin A	51.08	0.4	Gancao
MOL004857	Gancaonin B	48.79	0.45	Gancao
MOL004860	Licorice glycoside E	32.89	0.27	Gancao
MOL004863	3-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-enyl)chromone	66.37	0.41	Gancao
MOL004864	5,7-Dihydroxy-3-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromone	30.49	0.41	Gancao
MOL004866	2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-(3-methylbut-2-enyl)chromone	44.15	0.41	Gancao
MOL004879	Glycyrin	52.61	0.47	Gancao
MOL004882	Licocoumarone	33.21	0.36	Gancao
MOL004883	Licoisoflavone	41.61	0.42	Gancao
MOL004884	Licoisoflavone B	38.93	0.55	Gancao
MOL004885	Licoisoflavanone	52.47	0.54	Gancao
MOL004891	Shinpterocarpin	80.3	0.73	Gancao
MOL004898	(E)-3-[3,4-Dihydroxy-5-(3-methylbut-2-enyl)phenyl]-1-(2,4-dihydroxyphenyl)	46.27	0.31	Gancao
MOL004898	prop-2-en-1-one
MOL004903	Liquiritin	65.69	0.74	Gancao
MOL004904	Licopyranocoumarin	80.36	0.65	Gancao
MOL004905	3,22-Dihydroxy-11-oxo-delta(12)-oleanene-27-alpha-methoxycarbonyl-29-oic acid	34.32	0.55	Gancao
MOL004907	Glyzaglabrin	61.07	0.35	Gancao
MOL004908	Glabridin	53.25	0.47	Gancao
MOL004910	Glabranin	52.9	0.31	Gancao
MOL004911	Glabrene	46.27	0.44	Gancao
MOL004912	Glabrone	52.51	0.5	Gancao
MOL004913	1,3-Dihydroxy-9-methoxy-6-benzofurano[3,2-c]chromenone	48.14	0.43	Gancao
MOL004914	1,3-Dihydroxy-8,9-dimethoxy-6-benzofurano[3,2-c]chromenone	62.9	0.53	Gancao
MOL004915	Eurycarpin A	43.28	0.37	Gancao
MOL004917	Glycyroside	37.25	0.79	Gancao
MOL004924	(-)-Medicocarpin	40.99	0.95	Gancao
MOL004935	Sigmoidin-B	34.88	0.41	Gancao
MOL004941	(2R)-7-Hydroxy-2-(4-hydroxyphenyl) chroman-4-one	71.12	0.18	Gancao
MOL004945	(2S)-7-Hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one	36.57	0.32	Gancao
MOL004948	Isoglycyrol	44.7	0.84	Gancao
MOL004949	Isolicoflavonol	45.17	0.42	Gancao
MOL004957	HMO	38.37	0.21	Gancao
MOL004959	1-Methoxyphaseollidin	69.98	0.64	Gancao
MOL004961	Quercetin der.	46.45	0.33	Gancao
MOL004966	3′-Hydroxy-4′-O-methylglabridin	43.71	0.57	Gancao
MOL000497	Licochalcone a	40.79	0.29	Gancao
MOL004974	3′-Methoxyglabridin	46.16	0.57	Gancao
MOL004978	2-[(3R)-8,8-Dimethyl-3,4-dihydro-2H-	36.21	0.52	Gancao
	pyrano[6,5-f]chromen-3-yl]-5-
	methoxyphenol
MOL004980	Inflacoumarin A	39.71	0.33	Gancao
MOL004985	Icos-5-enoic acid	30.7	0.2	Gancao
MOL004988	Kanzonol F	32.47	0.89	Gancao
MOL004989	6-Prenylated eriodictyol	39.22	0.41	Gancao
MOL004990	7,2′,4′-Trihydroxy-5-methoxy-3-	83.71	0.27	Gancao
MOL004990	arylcoumarin
MOL004991	7-Acetoxy-2-methylisoflavone	38.92	0.26	Gancao
MOL004993	8-Prenylated eriodictyol	53.79	0.4	Gancao
MOL004996	Gadelaidic acid	30.7	0.2	Gancao
MOL000500	Vestitol	74.66	0.21	Gancao
MOL005000	Gancaonin G	60.44	0.39	Gancao
MOL005001	Gancaonin H	50.1	0.78	Gancao
MOL005003	Licoagrocarpin	58.81	0.58	Gancao
MOL005007	Glyasperins M	72.67	0.59	Gancao
MOL005008	Glycyrrhiza flavonol A	41.28	0.6	Gancao
MOL005012	Licoagroisoflavone	57.28	0.49	Gancao
MOL005013	18α-Hydroxyglycyrrhetic acid	41.16	0.71	Gancao
MOL005016	Odoratin	49.95	0.3	Gancao
MOL005017	Phaseol	78.77	0.58	Gancao
MOL005018	Xambioona	54.85	0.87	Gancao
MOL005020	Dehydroglyasperins C	53.82	0.37	Gancao
MOL000098	Quercetin	46.43	0.28	Gancao