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S. No | Propolis type | Medical applications | Mian result | References |
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1 | Green, red, or brown propolis | Atherosclerosis | Reduce atherosclerotic lesion area regulating inflammatory and angiogenic factors | [15] |
2 | Istanbul, Turkey propolis | Diabetes | Decrease of blood glucose significant improvement in pancreas, liver and kidney tissue | [16] |
3 | Brazilian extract of propolis (EEP) | Oral health | Effectively remove dental improve marginal periodontal tissue | [17] |
4 | Propolis | Radiation resistance | Inducing apoptosis increase the phosphorylation of Akt/mTOR and hinder cell migration | [18] |
5 | Brazilian propolis | Anti-ulcer effect | Inhibition of diclofenac induced ulcer formation antagonism to histaminergic system | [19] |
6 | Trigona sp. propolis | Dental pulp disease | Inhibition of IL-6 expression in dental pulp of inflammatory rats | [20] |
7 | Brown propolis from Southern Brazil | Anti-angiogenesis | Inhibition of tubular structure formation of endothelial cells on matrix gel (tubulogenesis) | [21] |
8 | Australian propolis extract (AP-1) | Antitumor activity | Promoting apoptosis and enhancing the anticancer activity of dox promote necrosis reversion to programmed cell death | [22] |
9 | Ethanol-soluble derivative of propolis | Protect liver activity | Elimination of hepatic collagen deposition, inflammatory signals and oxidative stress | [23] |
10 | Propolis extract | Vaginal use | Reorganization of vaginal mucosa faster organizational recovery decreased inflammatory response | [24] |
11 | Tekirdag-Turkey propolis | Antitumor activity | Activation of caspase cascade pathway induces apoptosis in C6 glioma cells | [25] |
12 | Ethanolic extract of propolis of Chihuahua (EEPCh) | Hypoglycemic effect | Significantly inhibited the increase of blood glucose and weight loss in diabetes mice | [26] |
13 | Populus-type propolis raw materials | Regulating blood lipids | Improvement of carotid restenosis in hypercholesterolemic rabbits inhibit neointimal hyperplasia reduce blood lipid level enhance antioxidant activity | [27] |
14 | Tehran, Iran propolis | Cardioprotective effect | Reduce oxidative stress, myocardial enzymes, histopathological degeneration and COX-2 expression in myocardial tissue | [28] |
15 | Korean propolis | Gastrointestinal diseases | Inhibit MAPK and NF-κB signal activation effectively inhibited the pro-inflammatory response induced by Helicobacter pylori | [29] |
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