Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing

Table 1

Treatment of other diseases with propolis.

S. No	Propolis type	Medical applications	Mian result	References
1	Green, red, or brown propolis	Atherosclerosis	Reduce atherosclerotic lesion area regulating inflammatory and angiogenic factors	[15]
2	Istanbul, Turkey propolis	Diabetes	Decrease of blood glucose significant improvement in pancreas, liver and kidney tissue	[16]
3	Brazilian extract of propolis (EEP)	Oral health	Effectively remove dental improve marginal periodontal tissue	[17]
4	Propolis	Radiation resistance	Inducing apoptosis increase the phosphorylation of Akt/mTOR and hinder cell migration	[18]
5	Brazilian propolis	Anti-ulcer effect	Inhibition of diclofenac induced ulcer formation antagonism to histaminergic system	[19]
6	Trigona sp. propolis	Dental pulp disease	Inhibition of IL-6 expression in dental pulp of inflammatory rats	[20]
7	Brown propolis from Southern Brazil	Anti-angiogenesis	Inhibition of tubular structure formation of endothelial cells on matrix gel (tubulogenesis)	[21]
8	Australian propolis extract (AP-1)	Antitumor activity	Promoting apoptosis and enhancing the anticancer activity of dox promote necrosis reversion to programmed cell death	[22]
9	Ethanol-soluble derivative of propolis	Protect liver activity	Elimination of hepatic collagen deposition, inflammatory signals and oxidative stress	[23]
10	Propolis extract	Vaginal use	Reorganization of vaginal mucosa faster organizational recovery decreased inflammatory response	[24]
11	Tekirdag-Turkey propolis	Antitumor activity	Activation of caspase cascade pathway induces apoptosis in C6 glioma cells	[25]
12	Ethanolic extract of propolis of Chihuahua (EEPCh)	Hypoglycemic effect	Significantly inhibited the increase of blood glucose and weight loss in diabetes mice	[26]
13	Populus-type propolis raw materials	Regulating blood lipids	Improvement of carotid restenosis in hypercholesterolemic rabbits inhibit neointimal hyperplasia reduce blood lipid level enhance antioxidant activity	[27]
14	Tehran, Iran propolis	Cardioprotective effect	Reduce oxidative stress, myocardial enzymes, histopathological degeneration and COX-2 expression in myocardial tissue	[28]
15	Korean propolis	Gastrointestinal diseases	Inhibit MAPK and NF-κB signal activation effectively inhibited the pro-inflammatory response induced by Helicobacter pylori	[29]