Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing

Table 2

Effects of different forms of propolis on wound healing.

S. No	Propolis form	Experimental model	Main results	References
1	Propolis ointment	Square skin incision	Affect stimulating keratinocytes cell proliferation	[30]
2		Diabetic foot ulcer	Reduced ulcer area enhanced wound healing	[31]
3		Pulp wound	Maintain low inflammation and microbial cell population stimulating restorative dentin	[32]
4		Burn	Stimulates the accumulation of glycosaminoglycans on the wound surface required for granulation, tissue growth and wound closure to accelerate the repair of burn tissue	[33]
5		Chronic wound	Treatment of chronic wound infection caused by Proteus mirabilis	[34]
6		Cell CRL-7522	Enhance the proliferation, activation and growth of skin cells	[35]
7		Rat skin wound	Speed up wound healing high inflammatory cell infiltration rate higher granulation tissue	[36]
8	Propolis extract	Tooth pulp wound	Dentin tubules are arranged more orderly as pulp capping agent	[37]
9		Skin wound	Staphylococcus aureus and Staphylococcus epidermidis have inhibitory effects improve skin antibacterial effect	[38]
10		Damage caused by striking	Contains fibroblasts and collagen a large number of mitotic cells stimulate cell proliferation and tissue repair	[39]
11		Wound (about 11 mm)	Accelerate wound healing improve collagen deposition	[40]
12	Wound dressing containing propolis	Third degree burn wound	The area of the burn was reduced no inflammation and edema	[41]
13		Back incision	Fibroblast proliferation contributes to collagen deposition increased synthesis of natural hyaluronic acid	[42]
14	Propolis contains biocellulose membrane	Back and neck trauma	Wound healing improved fibroblast and collagen production increased	[43]
15		Wound (about 6 mm)	Tissue repair of contaminated wounds shorter time and better effect	[44]
16	Propolis and metal nanoparticles and biology medical thread combination	Surgically infected wound	Promote cell migration and proliferation gives effective antibacterial power to surgical sutures	[45]