Research Article

Traditional Chinese Medicine Shen-Yuan-Dan (SYD) Improves Hypoxia-Induced Cardiomyocyte Apoptosis in Neonatal Rats by Upregulating miR-24/Bim Pathway

Table 1

Composition of shen-yuan-dan.

English nameLatin nameChinese namePlace of production (province)Collecting time (season)Part usedAmount used (g)TCM efficacyPharmacological activity

Salvia miltiorrhiza BgeRadix SalviaeDanshenHubei, HenanSpring and autumnRoot and rootstock15Activating blood and removing stasis; inducing menstruation to relieve menalgia; eliminating the heart-fire; cooling-bloodInhibiting increase of blood serum level of triglycerides [15], reversing renal injury induced [16], reversing cerebral ischemia-reperfusion injury [17], relieving myocardial ischemia [18], ameliorating diabetic vascular injury [19]
Astragalus membranaceus BgeAstragalus propinquusHuangqiShandongAutumnRoot12Invigorating Qi for strengthening superficies; diuresis; promoting granulationInhibiting myocardial ischemia-reperfusion injury, myocardial hypertrophy, vascular endothelial dysfunction, coronary heart disease, atherosclerosis, cardiac fibrosis, viral myocarditis, and diabetes mellitus [20], exerting antioxidant activity [21]
Radix Pilose AsiabellCodonopsis RadixDangshenGansuAutumnRoot10Tonifying middle-Jiao and Qi; promote the production of body fluid; strengthening spleen; and tonifying lungPreventing hypoxia-induced platelet activation and resultant procoagulant state [22], promoting mouse immune function [23], inhibiting the development of diet-induced obesity and hyperlipidemia [24], and relieving myocardial ischemia-reperfusion injury [25]
Radix ScrophulariaeScrophularia ningpoensisXuanshenHebeiWinterRoot5Removing pathogenic heat from blood; nourishing yin for lowering fire; clearing toxic material, dispersing massReversing heart and cerebral ischemia/reperfusion injury [26], relieving diabetic nephropathy [27], inhibiting the ventricular remodeling induced by hypertension [28], attenuating arteriosclerosis [29]
Hirudo nipponica (Whitman)Whitmania pigra WhitmanShuizhiShandongSummer and autumnAll parts of the Hirudo3Broken blood stasis, pursue action of silt, stimulate the menstrual flowPromoting blood circulation and removing stasis [30], relieving atherosclerosis [31], alleviating thrombus burden [32], improving blood hyperviscosity and related metabolic disorders [33]
LumbricusPheretimaDilongNorth ChinaSummer and autumnAll parts5Dredging collaterals, relieving cough and asthma, clearing heat, diureticExerting anti-thrombus [34], reversing mitochondrial injury and pro-fibrotic events [35], protecting brain microvascular endothelial cells after oxygen-glucose deprivation/reperfusion [36]
Eupolyphaga sinensis (Walker)Eupolyphaga seu Steleophaga TubiechongNorth ChinaSummer and autumnAll parts5Broken blood stasis, reunion of fractured tendons and bonesRelieving atherosclerosis [37], exerting antiangiogenesis [38]
Rhizoma CorydalisCorydalis RhizomaYanhusuoZhejiang; JiangsuSummerTubers5Removing blood stasis; regulating Qi; and relieve painDegrading the blood clot and delaying the plasma recalcification time [39], inhibiting inflammation, myocardial fibrosis, and platelet aggregation [40], improving the hypercoagulable state [41]