Genistein: Therapeutic and Preventive Effects, Mechanisms, and Clinical Application in Digestive Tract Tumor

Figure 2

Pathways involving, apoptosis and epithelial–mesenchymal transition (EMT) effect by genistein in HT29 cell lines. EMT reverses genistein by enhancing the expression of E-cadherin and inhibition of N-cadherin; along with the control of ZEB1, EMT makers, TWIST1, and Snail2/slug. Genistein enhances the function of Bax/Bcl-2 and caspase-8 by impeding notch-1. A decrease in the notch-1 leads to the prevention of both NF-κB and p-NF-κB expression, resulting in EMT reduction. Adapted and modified from [99].