“A Review of Parquetina nigrescens (Afzel.) Bullock, A Plant for Traditional Medicine: Phytochemical and Pharmacological Properties”

Table 3

Reported cases of P. nigrescens toxicological assessment in mice.

Plant parts	Type of extraction	Experimental model/method	No. and names of test animals	Actual dosages administered	Dosages reported with toxic effects	Mortality	Duration of experiment	LC50(mg/kg)/(μg/mL)	Organs/body fluids affected	References
Whole	Reflux condensation		6 sprague-Dawley rats	400, 800, 1600 (mg/kg)	1600 mg/kg·p.o^a	None	6 weeks		Decreases WBC	[27]
Leaves	Aqueous extract	Brine shrimp lethality bioassay and toxicities (Lorke’s method)	27 swiss albino mice (male)	3000, 6000, 12000 (mg/kg)	12000 mg/kgbw^b	Yes (2/3) mice	28 days	32.34 μg/mL	Mild kidney interstitial fibrosis, mild glomerular hypercellularity, and mild liver microhemorrhages.	[43]
Leaf, aerial	Methanol extract	HaCaT keratinocytes	50 Wistar rats (male)	100, 300, 1000 (mg/kg)	100, 300 (mg/kg)	None	35 days		Renal hemorrhage and hepatic inflammation	[68]
Leaf, aerial	Methanol extract	HaCaT keratinocytes	50 Wistar rats (male)	100, 300, 1000 (mg/kg)	100,300, 1000 (mg/kg)	None	35 days		Decreased WBC	[68]
Root			40 Wistar rats (male)	50, 100, 150 (mg/kg)	50,100 (mg/kg)		21 days		Decreased WBC	[26]
Root		Automated haematological analyzer systemex KX-21 (Japan)	40 wistar rats (male)	50, 100, 150 (mg/kg)	50 mg/kg		21 days		Decreased Eosinophil count	[26]

a = acute; b = sub-acute. Source: Reported cases of P. nigrescens toxicological assessment in mice was generated by the Authors.