Jiedu-Yizhi Formula Improves Cognitive Impairment in an A<i>β</i><sub>25–35</sub>-Induced Rat Model of Alzheimer’s Disease by Inhibiting Pyroptosis

<div>Compared to MG, oral administration of JDYZF and donepezil can reduce the expression levels of NLRP3, GSDMD, pro-caspase-1, and caspase-1 p20 in AD rats hippocampi (a). In addition, by reducing the expression of caspase-11 precursor and spliceosome, the activity of the nonclassical pyrolysis pathway is inhibited and the cognitive impairment of AD rats is improved (b). 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Evidence-Based Complementary and Alternative Medicine

fig4

Figure 4

Figure 4: Jiedu-Yizhi Formula Improves Cognitive Impairment in an A<i>β</i><sub>25–35</sub>-Induced Rat Model of Alzheimer’s Disease by Inhibiting Pyroptosis 

Evidence-Based Complementary and Alternative Medicine

Jiedu-Yizhi Formula Improves Cognitive Impairment in an Aβ25–35-Induced Rat Model of Alzheimer’s Disease by Inhibiting Pyroptosis

Figure 4

Jiedu-Yizhi Formula Improves Cognitive Impairment in an Aβ_25–35-Induced Rat Model of Alzheimer’s Disease by Inhibiting Pyroptosis