Gastroprotective Effect of Polypeptide-K Isolated from Momordica charantia’s Seeds on Multiple Experimental Gastric Ulcer Models in Rats

Table 1

Antiulcerogenic effect of PPK against HCl/EtOH.

Groups	Dose (mg/kg)	Total area of lesion (mm^2)	Inhibition (%)
HCl/EtOH only	-	44.67 ± 3.45	-
HCl/EtOH + ranitidine	100	30.33 ± 2.81	32.2%
HCl/EtOH + PPK	10	35.67 ± 3.84	20.1%
HCl/EtOH + PPK	25	33.16 ± 4.13	25.7%
HCl/EtOH + PPK	50	15.67 ± 2.67	64.9%

Statistical analysis was conducted utilizing one-way ANOVA followed by Dunnet’s post hoc test (n = 6), and data are expressed as mean ± SEM. Significantly different from HCl/EtOH group at 0.05 or at .