Gastroprotective Effect of Polypeptide-K Isolated from Momordica charantia’s Seeds on Multiple Experimental Gastric Ulcer Models in Rats
Table 2
Histopathological effect of polypeptide K (PPK) on HCl/EtOH-induced gastric ulcer in rats.
Groups/features
Normal
Edema and/or vacuolation
Epithelial disruption
Erosion extending to the muscularis mucosae
HCl/EtOH only
0.67 ± 0.21
2.67 ± 0.42
5.00 ± 0.63
3.33 ± 0.67
HCl/EtOH + ranitidine (100 mg/kg)
1.50 ± 0.22
1.00 ± 0.45
1.50 ± 0.67
0.67 ± 0.67
HCl/EtOH + PPK (10 mg/kg)
0.83 ± 0.17
1.33 ± 0.42
3.50 ± 0.92
1.33 ± 0.84
HCl/EtOH + PPK (25 mg/kg)
1.50 ± 0.22
2.00 ± 0.52
2.50 ± 0.92
2.00 ± 0.89
HCl/EtOH + PPK (50 mg/kg)
1.50 ± 0.22
2.67 ± 0.42
1.50 ± 0.67
0.67 ± 0.67
Values are expressed as mean + SEM (n = 6). indicates significant difference against HCl/EtOH only group. HCl/EtOH: hydrochloride acid/ethanol; PPK: polypeptide K.
