Gastroprotective Effect of Polypeptide-K Isolated from Momordica charantia’s Seeds on Multiple Experimental Gastric Ulcer Models in Rats

Table 4

Histopathological effect of polypeptide K (PPK) on indomethacin-induced gastric ulcer in rats.

Groups/features	Normal	Edema and/or vacuolation	Epithelial disruption	Erosion extending to the muscularis mucosae
Indomethacin only	0.83 ± 0.17	4.33 ± 0.84	5.00 ± 0.97	4.00 ± 1.03
Indomethacin + ranitidine (100 mg/kg)	2.67 ± 0.42	2.00 ± 0.52	2.00 ± 0.63	1.33 ± 0.84
Indomethacin + PPK (10 mg/kg)	1.00 ± 0.37	3.33 ± 0.67	4.00 ± 0.63	2.67 ± 0.84
Indomethacin + PPK (25 mg/kg)	1.67 ± 0.33	2.33 ± 0.61	2.50 ± 0.92	1.33 ± 0.84
Indomethacin + PPK (50 mg/kg)	2.00 ± 0.52	1.67 ± 0.33	1.50 ± 0.67	0.67 ± 0.67

Values are represented as the mean + SEM (n = 6). indicates significant difference against HCl/EtOH only group. PPK: polypeptide K.