Research Article
Gastroprotective Effect of Polypeptide-K Isolated from Momordica charantia’s Seeds on Multiple Experimental Gastric Ulcer Models in Rats
Table 5
Effect of PPK on gastric juice parameters in pylorus-ligated rats.
| | Groups | Volume (mL) | pH (unit) | Total acidity (m equiv./L) | Ulcer area (mm2) | Protection (%) |
| | Control | 5.50 ± 0.83 | 3.73 ± 0.04 | 5847 ± 308 | 25.80 ± 2.79 | - | | Ranitidine (100 mg/kg) | 3.82 ± 0.65 | 4.00 ± 0.26 | 2707 ± 330 | 8.75 ± 0.75 | 66.09% | | PPK (10 mg/kg) | 4.35 ± 0.88 | 3.07 ± 0.20 | 4813 ± 512 | 10.90 ± 1.67 | 57.75% | | PPK (25 mg/kg) | 3.50 ± 0.75 | 3.18 ± 0.17 | 4893 ± 538 | 8.30 ± 1.65 | 67.83% | | PPK (50 mg/kg) | 4.50 ± 0.60 | 3.47 ± 0.32 | 3926 ± 559 | 7.72 ± 1.69 | 70.08% |
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Results are presented as mean ± SEM ( n = 6). and indicate significant difference compared to indomethacin only group. |
