Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Table 3

Effect of A. mexicana fruit solvent fractions on percentage wound contraction in rats.

Days of wound area measurement in mm^2 (mean ± SEM) and % of contraction
Test Group	Day 3	Day 6	Day 9	Day 12	Day 15	Day 18
SO	258.27 ± 26.87 (097)	244.32 ± 26.26 (6.36)	189.99 ± 36.00 (47.76)	147.40 ± 34.58 (55.98)	105.08 ± 7.52 (58.81)	79.63 ± 11.25 (66.84)
MEBO	217.42 ± 8.45^acdfg (13.03)	168.30 ± 6.79^#af (32.68)	103.28 ± 3.68^#af (60.12)	61.88 ± 11.88^#af (75.25)	19.61 ± 15.11^#af (92.16)	2.33 ± 1.25^#acf (99.07)
5% EAF	242.31 ± 2.64 (3.08)	182.17 ± 3.61^a (27.13)	131.34 ± 1.53^af (35.32)	98.73 ± 1.10^a (60.51)	49.36 ± 1.90^af (80.25)	13.58 ± 3.15^af (94.57)
10% EAF	229.22 ± 2.58^ad (8.31)	171.50 ± 3.11^adf (31.40)	109.21 ± 1.72^#af (59.16)	74.23 ± 6.92^#acf (70.31)	27.07^acdf (89.17)	4.65 ± 4.49^#af (98.14)
5% n-HF	255.06 ± 21.48 (2.02)	204.49 ± 40.15 (18.21)	123.20 ± 29.46^#a (32.53)	90.06 ± 34.09^af (63.98)	46.13 ± 14.01^af (81.55)	13.57 ± 1.02^af (94.57)
10% n-HF	232.52 ± 2.51^a (7.1)	173.96 ± 3.8^a (30.41)	112.74 ± 1.66^#af (36.77)	80.44 ± 8.28^af (67.82)	24.86 ± 11.53^acf (90.06)	8.77 ± 2.21^#af (96.49)
5% AF	246.93 ± 2.95 (1.23)	210.16 ± 5.62 (15.94)	167.12 ± 2.08 (48.81)	127.97 ± 6.93 (49.61)	89.77 ± 13.56^af (64.09)	34.04 ± 18.48^a (86.39)
10% AF	241.82 ± 3.04 (3.28)	193.89 ± 5.18^af (22.45)	117.23 ± 3.15^af (52.39)	89.17 ± 1.65^a (64.33)	29.27 ± 13.68^af (88.29)	11.83 ± 0.66^af (95.27)

Values are expressed as mean ± SEM (n = 6 rats in each group) and analyzed by one-way ANOVA followed by post hoc Tuckey’s test; ^acompared with simple ointment; ^bcompared with MEBO ^ccompared with 5% EAF; ^dcompared with 5% n-HF, ^ecompared with 10% n-HF;^fcompared with 5% AF, ^gcompared with 10% AF; w/w = weight by weight; SO = simple ointment; ; ^# = ; MEBO = moist-exposed burn ointment; EAF, n-HF & AF are ethyl acetate, n-hexane, and aqueous fractions of A. Mexicana, respectively. The initial wound area was 250 mm². Values in the bracket are % of contractions.